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q-bio.QM2023
TemPL: A Novel Deep Learning Model for Zero-Shot Prediction of Protein Stability and Activity Based on Temperature-Guided Language Modeling
Pan Tan, Mingchen Li, Liang Zhang +2
We introduce TemPL, a novel deep learning approach for zero-shot prediction of protein stability and activity, harnessing temperature-guided language modeling. By assembling an ext…
q-bio.QM2022★ 39 cited
SESNet: sequence-structure feature-integrated deep learning method for data-efficient protein engineering
Mingchen Li, Liqi Kang, Yi Xiong +4
Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functio…