87 citations · 87 across the 3 of their papers we have counts for
4 papers
Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach
Salvador Chulián, Alvaro Martínez-Rubio, Anna Marciniak-Czochra +7
Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process ar…
A structured population model of clonal selection in acute leukemias with multiple maturation stages
Tommaso Lorenzi, Anna Marciniak-Czochra, Thomas Stiehl
Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain un…
Oscillations in a white blood cell production model with multiple differentiation stages
Franziska Knauer, Thomas Stiehl, Anna Marciniak-Czochra
In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analyti…
Clonal selection and therapy resistance in acute leukemias: Mathematical modelling explains different proliferation patterns at diagnosis and relapse
Thomas Stiehl, Natalia Baran, Anthony D. Ho +1
Recent experimental evidence suggests that acute myeloid leukemias may originate from multiple clones of malignant cells. Nevertheless it is not known how the observed clones may d…