2 papers
math.AP2019
A structured population model of clonal selection in acute leukemias with multiple maturation stages
Tommaso Lorenzi, Anna Marciniak-Czochra, Thomas Stiehl
Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain un…
math.DS2018
Oscillations in a white blood cell production model with multiple differentiation stages
Franziska Knauer, Thomas Stiehl, Anna Marciniak-Czochra
In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analyti…