195 citations · 399 across the 8 of their papers we have counts for
4 papers · 1 filter
Beyond the classical type I error: Bayesian metrics for Bayesian designs using informative priors
Nicky Best, Maxine Ajimi, Beat Neuenschwander +2
There is growing interest in Bayesian clinical trial designs with informative prior distributions, e.g. for extrapolation of adult data to pediatrics, or use of external controls.…
Using phase II data for the analysis of phase III studies: an application in rare diseases
Simon Wandel, Beat Neuenschwander, Tim Friede +1
Clinical research and drug development in orphan diseases is challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is there…
Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases
Tim Friede, Christian Röver, Simon Wandel +1
Random-effects meta-analyses are used to combine evidence of treatment effects from multiple studies. Since treatment effects may vary across trials due to differences in study cha…
Meta-analysis of few small studies in orphan diseases
Tim Friede, Christian Röver, Simon Wandel +1
Meta-analyses in orphan diseases and small populations generally face particular problems including small numbers of studies, small study sizes, and heterogeneity of results. Howev…