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math.ST2015
Optimal Approximate Designs for Comparison with Control in Dose-Escalation Studies
Samuel Rosa, Radoslav Harman
Consider an experiment, where a new drug is tested for the first time on human subjects - healthy volunteers. Such experiments are often performed as dose-escalation studies: a set…
math.ST2015★ 10 cited
Optimal approximate designs for estimating treatment contrasts resistant to nuisance effects
Samuel Rosa, Radoslav Harman
Suppose that we intend to perform an experiment consisting of a set of independent trials. The mean value of the response of each trial is assumed to be equal to the sum of the eff…