1 citations · 1 across the 3 of their papers we have counts for
6 papers
Fundamental limits of accuracy and precision in single molecule biosensors
Tuhin Chakrabortty, Manoj M Varma
Physical limit of molecular sensing has been extensively studied in biological systems. Biosensors are engineered equivalents of molecular sensors in living systems and play critic…
Equilibrium Probability Distribution for Number of Bound Receptor-Ligand Complexes
Tuhin Chakrabortty, Manoj M Varma
The phenomenon of molecular binding, where two molecules, referred to as a receptor and a ligand, bind together to form a ligand-receptor complex, is ubiquitous in biology and esse…
Theoretical Limit Of Concentration Sensing of Single Receptor Artificial Biosensors
Tuhin Chakrabortty, Manoj M Varma
Artificially engineered biosensors are highly inefficient in accurately measuring the concentration of biomarkers, particularly, during early diagnosis of diseases. On the other ha…
Error reduction in biosensors using secondary labeling
Tuhin Chakrabortty, Manoj M Varma
In this article, we derive the limit of detection for a two-step molecular recognition process and show that in-spite of all the recognition reactions being in equilibrium the over…
Fundamental Limitations in Biomarker Based Early Disease Diagnosis
Tuhin Chakrabortty, Chandra R. Murthy, Manoj Varma
Clinical biosensors with low detection limit hold significant promise in the early diagnosis of debilitating diseases. Recent progress in sensor development has led to the demonstr…
A Null-model Exhibiting Synchronized Dynamics in Uncoupled Oscillators
Tuhin Chakrabortty, Akash Suman, Anjali Gupta +2
The phenomenon of phase synchronization of oscillatory systems arising out of feedback coupling is ubiquitous across physics and biology. In noisy, complex systems, one generally o…