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20182025
most citedDouble Diffusion Encoding Prevents Degeneracy in Parameter Estimation of Biophysical Models in Diffusion MRI

81 citations · 146 across the 9 of their papers we have counts for

collaborators

9 papers

physics.med-ph2025

What if each voxel were measured with a different diffusion protocol?

Santiago Coelho, Gregory Lemberskiy, Ante Zhu +5

Expansion of diffusion MRI (dMRI) both into the realm of strong gradients, and into accessible imaging with portable low-field devices, brings about the challenge of gradient nonli…

physics.med-ph2024

Geometry of the cumulant series in diffusion MRI

Santiago Coelho, Jenny Chen, Filip Szczepankiewicz +2

Water diffusion gives rise to micron-scale sensitivity of diffusion MRI (dMRI) to cellular-level tissue structure. Precision medicine and quantitative imaging depend on uncovering…

physics.med-ph2024★ 12 cited

Denoising Improves Cross-Scanner and Cross-Protocol Test-Retest Reproducibility of Higher-Order Diffusion Metrics

Benjamin Ades-Aron, Santiago Coelho, Gregory Lemberskiy +5

The clinical translation of diffusion MRI (dMRI)-derived quantitative contrasts hinges on robust reproducibility, minimizing both same-scanner and cross-scanner variability. This s…

physics.med-ph2024★ 3 cited

Assessment of Precision and Accuracy of Brain White Matter Microstructure using Combined Diffusion MRI and Relaxometry

Santiago Coelho, Ying Liao, Filip Szczepankiewicz +5

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter,…

physics.bio-ph2023★ 19 cited

Volume electron microscopy in injured rat brain validates white matter microstructure metrics from diffusion MRI

Ricardo Coronado-Leija, Ali Abdollahzadeh, Hong-Hsi Lee +8

Biophysical modeling of diffusion MRI (dMRI) offers the exciting potential of bridging the gap between the macroscopic MRI resolution and microscopic cellular features, effectively…

physics.med-ph2023★ 29 cited

Mapping tissue microstructure of brain white matter in vivo in health and disease using diffusion MRI

Ying Liao, Santiago Coelho, Jenny Chen +7

Diffusion magnetic resonance imaging offers unique in vivo sensitivity to tissue microstructure in brain white matter, which undergoes significant changes during development and is…

physics.bio-ph2022★ 2 cited

Reproducibility of the Standard Model of diffusion in white matter on clinical MRI systems

Santiago Coelho, Steven H. Baete, Gregory Lemberskiy +5

Estimating intra- and extra-axonal microstructure parameters, such as volume fractions and diffusivities, has been one of the major efforts in brain microstructure imaging with MRI…

physics.med-ph2019

Optimal experimental design for biophysical modelling in multidimensional diffusion MRI

Santiago Coelho, Jose M. Pozo, Sune N. Jespersen +1

Computational models of biophysical tissue properties have been widely used in diffusion MRI (dMRI) research to elucidate the link between microstructural properties and MR signal…

physics.bio-ph2018★ 81 cited

Double Diffusion Encoding Prevents Degeneracy in Parameter Estimation of Biophysical Models in Diffusion MRI

Santiago Coelho, Jose M. Pozo, Sune N. Jespersen +2

Purpose: Biophysical tissue models are increasingly used in the interpretation of diffusion MRI (dMRI) data, with the potential to provide specific biomarkers of brain microstructu…