61 citations · 150 across the 15 of their papers we have counts for
15 papers
Exploratory Simulation of Thrombosis in a Temporary LVAD Catheter Pump within a Virtual In-vivo Left Heart Environment
Greg W. Burgreen, Mansur Zhussupbekov, Rodrigo Méndez Rojano +1
Percutaneous catheter pumps are intraventricular temporary mechanical circulatory support (MCS) devices that are positioned across the aortic valve into the left ventricle (LV) and…
In Vitro and In Silico Characterization of the Aggregation of Thrombi on Ventricular Assist Device Cannula
Wenxuan He, Abhishek Karmakar, Grant Rowlands +3
The unacceptably high stroke rate of HeartMate III VAD without signs of adherent pump thrombosis is hypothesized to be the result of the thrombi originating on the inflow cannula,…
Automated CFD shape optimization of stator blades for the PediaFlow pediatric ventricular assist device
Mansur Zhussupbekov, Greg W Burgreen, Jeongho Kim +1
PediaFlow is a miniature mixed-flow ventricular assist device for neonates and toddlers. PediaFlow has a fully magnetically levitated rotor which improves biocompatibility, but the…
von Willebrand Factor unfolding mediates platelet deposition in a model of high-shear thrombosis
Mansur Zhussupbekov, Rodrigo Mendez Rojano, Wei-Tao Wu +1
Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Willebrand Factor (vWF). vWF unfolds in response to strong flow gradients and faci…
A continuum model for the unfolding of von Willebrand Factor
Mansur Zhussupbekov, Rodrigo Mendez Rojano, Wei-Tao Wu +2
von Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. I…
Uncertainty quantification of a thrombosis model considering the clotting assay PFA-100
Rodrigo Méndez Rojano, Mansur Zhussupbekov, James F. Antaki +1
Mathematical models of thrombosis are currently used to study clinical scenarios of pathological thrombus formation. Most of these models involve inherent uncertainties that must b…
Synergistic effect of shear and ADP on platelet growth on ZTA and Ti6Al4V surfaces
Anjana Jayaraman, Junhyuk Kang, Megan A. Jamiolkowski +3
Continuous-flow ventricular assist devices (VADs) have been an increasingly common, life-saving therapy for advanced heart-failure patients, but elevate the risk of thrombosis due…
Multi-scale simulation of thrombus formation at LVAD inlet cannula connection: Importance of Virchow's triad
R. Mendez Rojano, M. Zhussupbekov, J. F. Antaki
As pump thrombosis is reduced in current-generation ventricular assist devices (VAD), adverse events such as bleeding or stroke remain at unacceptable rates. Thrombosis around the…
Influence of shear rate and surface chemistry on thrombus formation in micro-crevice
Mansur Zhussupbekov, Wei-Tao Wu, Megan A. Jamiolkowski +2
Thromboembolic complications remain a central issue in management of patients on mechanical circulatory support. Despite the best practices employed in design and manufacturing of…
Limitations of ROC on Imbalanced Data: Evaluation of LVAD Mortality Risk Scores
Faezeh Movahedi, Rema Padman, James F. Antaki
Objective: This study illustrates the ambiguity of ROC in evaluating two classifiers of 90-day LVAD mortality. This paper also introduces the precision recall curve (PRC) as a supp…
Sequential Pattern mining of Longitudinal Adverse Events After Left Ventricular Assist Device Implant
Faezeh Movahedi, Robert L. Kormos, Lisa Lohmueller +6
Left ventricular assist devices (LVADs) are an increasingly common therapy for patients with advanced heart failure. However, implantation of the LVAD increases the risk of stroke,…
A non-linear fluid suspension model for blood flow
Wei-Tao Wu, Nadine Aubry, James F. Antaki +1
Motivated by the complex rheological behaviors observed in small/micro scale blood vessels, such as the Fahraeus effect, plasma-skimming, shear-thinning, etc., we develop a non-lin…
Transport of platelets induced by red blood cells based on mixture theory
Wei-Tao Wu, Nadine Aubry, James F. Antaki +1
Thrombosis is a common complication following the surgical implantation of blood contacting devices, and is strongly influenced by the phenomenon of near-wall enrichment of platele…
Normal stress effects in the gravity driven flow of granular materials
Wei-Tao Wu, Nadine Aubry, James F. Antaki +1
In this paper, we study the fully developed gravity-driven flow of granular materials between two inclined planes. We assume that the granular materials can be represented by a mod…
Multi-Constituent Simulation of Thrombus Deposition
Wei-Tao Wu, Megan A. Jamiolkowski, William R. Wagner +3
In this paper, we present a spatio-temporal mathematical model for simulating the formation and growth of a thrombus. Blood is treated as a multi-constituent mixture comprised of a…