10 papers
Theory of associating polymers with annealed and quenched sticker disorder: Mean-field solution and phase behavior
Sofia Moschin, Achille Giacometti, Amos Maritan +1
We develop a density-functional theory for solutions of associating polymers where attractions among charged monomers (stickers) are represented by local binary degrees of freedom,…
Information Transmission and Processing in G-Protein-Coupled-Receptor Complexes
Roger D. Jones, Achille Giacometti, Alan M. Jones
G-protein-coupled receptors (GPCRs) are central to cellular information processing, yet the physical principles governing their switching behavior remain incompletely understood. W…
Plumbing Analog of Molecular Computation
Roger D. Jones, Achille Giacometti, Alan M. Jones
Biological information processing often arises from mesoscopic molecular systems operating far from equilibrium, yet their complexity can make the underlying principles difficult t…
Material-Based Intelligence: Self-organizing, Autonomous and Adaptive Cognition Embodied in Physical Substrates
Vladimir A. Baulin, Rudolf M. Füchslin, Achille Giacometti +2
The design of intelligent materials often draws parallels with the complex adaptive behaviors of biological organisms, where robust functionality stems from sophisticated hierarchi…
Thermodynamics of Biological Switches
Roger D. Jones, Achille Giacometti, Alan M. Jones
We derive a formulation of the First Law of nonequilibrium thermodynamics for biological information-processing systems by partitioning entropy in the Second Law into microscopic a…
Space-filling discrete helices
Jayanth R. Banavar, Achille Giacometti, Trinh X. Hoang +2
Proteins are linear chain molecules that play a central role in life and health. Protein native state folds are modular assemblies of space-filling building blocks of α-helices, \…