4 papers
Harmonised benchmarking of foundation models for single-cell and spatial transcriptomics reveals context-dependent generalisation
Sally Chen, Roxana Zahedi, Lucy Chhuo +11
Single-cell and spatial foundation models promise transferable biological representations, yet their generality remains largely untested across modalities, biological domains and a…
Transcriptomic Models for Immunotherapy Response Prediction Show Limited Cross-cohort Generalisability
Yuheng Liang, Lucy Chhuo, Ahmadreza Argha +8
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; yet substantial proportion of patients exhibit intrinsic or acquired resistance, making accurate pre-treatment…
SemanticST: Spatially Informed Semantic Graph Learning for Clustering, Integration, and Scalable Analysis of Spatial Transcriptomics
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi +4
Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogenei…
How chromatin interactions shed light on interpreting non-coding genomic variants: opportunities and future direc-tions
Yuheng Liang, Sedigheh Abedini, Nona Farbehi +1
Genomic variants, including copy number variants (CNVs) and genome-wide associa-tion study (GWAS) single nucleotide polymorphisms (SNPs), represent structural alterations that infl…