4 papers
Anti-seizure medication load is not correlated with early termination of seizure spread
Nathan Evans, Sarah J. Gascoigne, Guillermo M. Besne +11
Objective: Anti-seizure medications (ASMs) are the mainstay of treatment for epilepsy, yet their effect on seizure spread is not fully understood. Higher ASM doses have been associ…
Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Guillermo M. Besne, Emmanuel Molefi, Sarah J. Gascoigne +12
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by…
More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors
Billy C. Smith, Christopher Thornton, Rachel E. Stirling +7
Objective: The circadian rhythm synchronizes physiological and behavioural patterns with the 24-hour light-dark cycle. Disruption to the circadian rhythm is linked to various healt…
Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex
Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou +11
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, des…