most citedComputational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrepresented upstream motifs

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physics.bio-ph2002

Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in eukaryotes

M. Caselle, F. Di Cunto, P. Provero

Gene regulation in eukaryotes is mainly effected through transcription factors binding to rather short recognition motifs generally located upstream of the coding region. We presen…

physics.bio-ph2002

Finding regulatory sites from statistical analysis of nucleotide frequencies in the upstream region of eukaryotic genes

M. Caselle, F. Di Cunto, M. Pellegrino +1

We discuss two new approaches to extract relevant biological information on the Transcription Factors (and in particular to identify their binding sequences) from the statistical d…