9 papers
How genome redundancy can promote evolutionary innovation
Domenico Caudo, Mattia Miotto, Giancarlo Ruocco +1
Polyploidy is defined as the existence of more than two complete sets of homologous chromosomes. Despite it being a widespread phenomenon across the tree of life, its role as eithe…
Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies
Mattia Miotto, Giancarlo Ruocco, Matteo Paoluzzi
Eukaryotic cells are characterized by a stiff nucleus whose effect in modeling the collective behavior of cell aggregates is usually underestimated. However, increasing experimenta…
Deciphering the chemical grammar of protein-RNA condensates
Greta Grassmann, Giancarlo Ruocco, Mattia Miotto
Biomolecular phase separation is typically attributed to the polymer physics of long, disordered chains. However, the underlying chemical grammar, i.e. the specific interactions be…
Emergent learning: neuromorphic photonic computing with accelerated training
Sara Peña-Gutiérrez, Giorgio Gosti, Hongsheng Chen +2
Emergent learning transforms a disordered optical medium into a photonic device capable of storage, recognition, and classification of arbitrary memory patterns. First, we show tha…
Robust assessment of asymmetric division in colon cancer cells
Domenico Caudo, Chiara Giannattasio, Simone Scalise +6
Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to inc…
A mother-machine microfluidic device for non-adherent mammalian cells reveals the population growth strategies
Simone Scalise, Giovanna Peruzzi, Davide Caprini +3
We develop a mother machine-like microfluidic device specifically designed to track the proliferation of T-cells via live-cell microscopy. Although numerous microfluidic setups hav…