On inferring the ion selectivity of the KcsA potassium channel using the distribution of coordination states of the aqueous ions

P. D. Dixit, S. Merchant, D. Asthagiri

The S${}_2$ site of the KcsA K${}^{+}$ channel has eight carbonyl ligands in the ion-binding site. A recent study suggests that the K${}^{+}$-over-Na${}^{+}$ selectivity of the S${}_2$ site can be…