5 papers
Validation of Sinus Drug Delivery Computational Fluid Dynamics (CFD) Modeling with In Vitro Gamma Scintigraphy
K. Kudlaty, W. Bennett, L. Holbrook +10
Background: Chronic rhinosinusitis (CRS) is a prevalent and disruptive disease. Medical management including nasal steroid sprays is the primary treatment modality. Computational f…
Numerical evaluation of spray position for improved nasal drug delivery
Saikat Basu, Landon T Holbrook, Kathryn Kudlaty +16
Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show…
Comparative Analysis of the Main Nasal Cavity and the Paranasal Sinuses in Chronic Rhinosinusitis: An Anatomic Study of Maximal Medical Therapy
Satyan B. Sreenath, Julia S. Kimbell, Saikat Basu +6
Objective: Minimal literature exists investigating changes in inflammation with respect to the main nasal cavity (MNC) and paranasal sinuses (PS) before and after maximal medical t…
Comparative Study of Simulated Nebulized and Spray Particle Deposition in Chronic Rhinosinusitis Patients
Zainab Farzal, Saikat Basu, Alyssa Burke +7
Introduction: Topical intranasal drugs are widely prescribed for Chronic Rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was…
On computational fluid dynamics models for sinonasal drug transport: relevance of nozzle subtraction and nasal vestibular dilation
Saikat Basu, Dennis O. Frank-Ito, Julia S. Kimbell
Generating anatomically realistic three-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodologic…