5 papers
Analysis of inter-spike interval statistics in neuronal networks with depolarizing and hyperpolarizing threshold potentials
Oliver Gambrell, Abhyudai Singh
Neuronal communication is mediated in part by changes in neuronal firing rates. The time interval between successive neuronal firings is referred to as the inter-spike interval (IS…
Stochastic multi-step cell size homeostasis model for cycling human cells
Sayeh Rezaee, Cesar Nieto, Abhyudai Singh
Measurements of cell size dynamics have established the adder principle as a robust mechanism of cell size homeostasis. In this framework, cells add a nearly constant amount of siz…
Intrinsic limits of timekeeping precision in gene regulatory cascades
Juan Sebastian Hernandez, Cesar Nieto, Juan Manuel Pedraza +1
Multiple cellular processes are triggered when the concentration of a regulatory protein reaches a critical threshold. Previous analyses have characterized timing statistics for si…
Dynamical Inference of Cell Size Regulation Parameters
Cesar Nieto, Sayeh Rezaee, Cesar Augusto Vargas-Garcia +1
Cells achieve size homeostasis by regulating their division timing based on their size, added size, and cell cycle time. Previous research under steady-state conditions demonstrate…
Information and fitness in two-state systems: self-replicating individuals in a fluctuating environment
Poulami Chatterjee, Cesar Nieto, Juan Manuel Pedraza +1
A population of individuals with the same genes can present heterogeneous traits (phenotypes). The prevalence of this heterogeneity can be explained as a bet-hedging strategy that…