activity
20122025
most citedLow-signal limit of X-ray single particle imaging

46 citations · 174 across the 21 of their papers we have counts for

collaborators

25 papers

physics.optics2025

Nonlinear phenomena in X-ray fluorescence from single nanoparticles under extreme conditions

Sebastian Cardoch, Tamme Wollweber, Sarodi Jonak Dutta +26

Materials exposed to intense femtosecond X-ray pulses with energies above their K-shell absorption edge can enter an extremely ionized state, which could give rise to nonlinear phe…

physics.optics2025

Single-particle incoherent diffractive imaging and amplified spontaneous emission in copper nanocubes

Tamme Wollweber, Sarodi Jonak Dutta, Zhou Shen +26

We demonstrate element-specific incoherent diffractive imaging (IDI) of single copper nanocubes using intensity correlations of K fluorescence at a hard X-ray free-electron lase…

cond-mat.mes-hall2025

Single-Particle X-ray Scattering Reveals a High Local Supersaturation of Precursors as the Origin of CoO Assembly Formation

Sani Y. Harouna-Mayer, Lars Klemeyer, Cecilia A. Zito +24

Single-particle small-angle X-ray scattering (SP-SAXS) enables quantitative morphological analysis by recording diffraction snapshots from isolated particles using X-ray free-elect…

physics.optics2025

High-background X-ray single particle imaging enabled by holographic enhancement with 2D crystals

Abhishek Mall, Zhou Shen, Kartik Ayyer

X-ray single particle imaging (SPI) has offered the potential to visualize structures of biomolecules at near-atomic resolution. However, state-of-the-art structures at X-ray free…

cond-mat.mtrl-sci2025

Direct observation of the exciton polaron by serial femtosecond crystallography on single CsPbBr quantum dots

Zhou Shen, Margarita Samoli, Onur Erdem +28

The outstanding opto-electronic properties of lead halide perovskites have been related to the formation of polarons. Nevertheless, the observation of the atomistic deformation bro…

physics.optics2024★ 2 cited

SPRING: an effective and reliable framework for image reconstruction in single-particle Coherent Diffraction Imaging

Alessandro Colombo, Mario Sauppe, Andre Al Haddad +40

Coherent Diffraction Imaging (CDI) is an experimental technique to gain images of isolated structures by recording the light scattered off the sample. In principle, the sample dens…

q-bio.BM2024

Observation of Aerosolization-induced Morphological Changes in Viral Capsids

Abhishek Mall, Anna Munke, Zhou Shen +27

Single-stranded RNA viruses co-assemble their capsid with the genome and variations in capsid structures can have significant functional relevance. In particular, viruses need to r…

cond-mat.mes-hall2024

Resolving non-equilibrium shape variations amongst millions of gold nanoparticles

Zhou Shen, Salah Awel, Anton Barty +36

Nanoparticles, exhibiting functionally relevant structural heterogeneity, are at the forefront of cutting-edge research. Now, high-throughput single-particle imaging (SPI) with x-r…

physics.optics2023

Nanoscale X-ray imaging with high spectral sensitivity using fluorescence intensity correlations

Tamme Wollweber, Kartik Ayyer

This paper introduces Spectral Incoherent Diffractive Imaging (SIDI) as a novel method for achieving dark-field imaging of nanostructures with heterogeneous oxidation states. With…

cond-mat.mes-hall2023★ 15 cited

Time-resolved single-particle x-ray scattering reveals electron-density as coherent plasmonic-nanoparticle-oscillation source

D. Hoeing, R. Salzwedel, L. Worbs +18

Dynamics of optically-excited plasmonic nanoparticles are presently understood as a series of sequential scattering events, involving thermalization processes after pulsed optical…

eess.IV2022

Holographic single particle imaging for weakly scattering, heterogeneous nanoscale objects

Abhishek Mall, Kartik Ayyer

Single particle imaging (SPI) at X-ray free electron lasers (XFELs) is a technique to determine the 3D structure of nanoscale objects like biomolecules from a large number of diffr…

physics.optics2022★ 1 cited

Ab Initio Spatial Phase Retrieval via Intensity Triple Correlations

Nolan Peard, Kartik Ayyer, Henry N. Chapman

Second-order intensity correlations from incoherent emitters can reveal the Fourier transform modulus of their spatial distribution, but retrieving the phase to enable completely g…

physics.acc-ph2022

On the use of multilayer Laue lenses with X-ray Free Electron Lasers

Mauro Prasciolu, Kevin T. Murray, Nikolay Ivanov +34

Multilayer Laue lenses were used for the first time to focus x-rays from an X-ray Free Electron Laser (XFEL). In an experiment, which was performed at the European XFEL, we demonst…

eess.IV2021★ 1 cited

Unsupervised learning approaches to characterize heterogeneous samples using X-ray single particle imaging

Yulong Zhuang, Salah Awel, Anton Barty +39

One of the outstanding analytical problems in X-ray single particle imaging (SPI) is the classification of structural heterogeneity, which is especially difficult given the low sig…

physics.ins-det2020

New aerodynamic lens injector for single particle diffractive imaging

Nils Roth, Daniel A. Horke, Jannik Lübke +17

An aerodynamic lens injector was developed specifically for the needs of single-particle diffractive imaging experiments at free-electron lasers. Its design allows for quick change…

physics.data-an2020★ 1 cited

An encryption-decryption framework for validating single-particle imaging

Zhou Shen, Colin Zhi Wei Teo, Kartik Ayyer +1

We propose an encryption-decryption framework for validating diffraction intensity volumes reconstructed using single-particle imaging (SPI) with x-ray free-electron lasers (XFELs)…

physics.app-ph2020

3D diffractive imaging of nanoparticle ensembles using an X-ray laser

Kartik Ayyer, P. Lourdu Xavier, Johan Bielecki +34

We report the 3D structure determination of gold nanoparticles (AuNPs) by X-ray single particle imaging (SPI). Around 10 million diffraction patterns from gold nanoparticles were m…

physics.optics2020★ 13 cited

Photon statistics and signal to noise ratio for incoherent diffraction imaging

Fabian Trost, Kartik Ayyer, Henry Chapman

Intensity interferometry is a well known method in astronomy. Recently, a related method called incoherent diffractive imaging (IDI) was proposed to apply intensity correlations of…

eess.IV2020★ 8 cited

Reference-enhanced X-ray Single Particle Imaging

Kartik Ayyer

X-ray single particle imaging involves the measurement of a large number of noisy diffraction patterns of isolated objects in random orientations. The missing information about the…

physics.ins-det2019★ 3 cited

Megahertz single-particle imaging at the European XFEL

Egor Sobolev, Serguey Zolotarev, Klaus Giewekemeyer +60

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimenta…

eess.IV2019★ 46 cited

Low-signal limit of X-ray single particle imaging

Kartik Ayyer, Andrew J. Morgan, Andrew A. Aquila +7

An outstanding question in X-ray single particle imaging experiments has been the feasibility of imaging sub 10-nm-sized biomolecules under realistic experimental conditions where…

physics.optics2017★ 45 cited

Incoherent Diffractive Imaging via Intensity Correlations of hard X-rays

Anton Classen, Kartik Ayyer, Henry N. Chapman +2

Established x-ray diffraction methods allow for high-resolution structure determination of crystals, crystallized protein structures or even single molecules. While these technique…

physics.optics2017

Continuous Diffraction of Molecules and Disordered Molecular Crystals

Henry N. Chapman, Oleksandr M. Yefanov, Kartik Ayyer +6

The diffraction pattern of a single non-periodic compact object, such as a molecule, is continuous and is proportional to the square modulus of the Fourier transform of that object…

physics.data-an2013★ 39 cited

Real-Space x-ray tomographic reconstruction of randomly oriented objects with sparse data frames

Kartik Ayyer, Hugh T. Philipp, Mark W. Tate +2

Schemes for X-ray imaging single protein molecules using new x-ray sources, like x-ray free electron lasers (XFELs), require processing many frames of data that are obtained by tak…