4 papers
Nonparametric Analysis of Delayed Treatment Effects using Single-Crossing Constraints
Nicholas C. Henderson, Kijoeng Nam, Dai Feng
Clinical trials involving novel immuno-oncology (IO) therapies frequently exhibit survival profiles which violate the proportional hazards assumption due to a delay in treatment ef…
Bayesian Bivariate Subgroup Analysis for Risk-Benefit Evaluation
Nicholas C. Henderson, Ravi Varadhan
Subgroup analysis is a frequently used tool for evaluating heterogeneity of treatment effect and heterogeneity in treatment harm across observed baseline patient characteristics. W…
Damped Anderson acceleration with restarts and monotonicity control for accelerating EM and EM-like algorithms
Nicholas C. Henderson, Ravi Varadhan
The expectation-maximization (EM) algorithm is a well-known iterative method for computing maximum likelihood estimates from incomplete data. Despite its numerous advantages, a mai…
Individualized Treatment Effects with Censored Data via Fully Nonparametric Bayesian Accelerated Failure Time Models
Nicholas C. Henderson, Thomas A. Louis, Gary L. Rosner +1
Individuals often respond differently to identical treatments, and characterizing such variability in treatment response is an important aim in the practice of personalized medicin…