54 citations · 81 across the 10 of their papers we have counts for
10 papers
Cardiac Digital Twin Pipeline for Virtual Therapy Evaluation
Julia Camps, Zhinuo Jenny Wang, Ruben Doste +6
Cardiac digital twins are computational tools capturing key functional and anatomical characteristics of patient hearts for investigating disease phenotypes and predicting response…
Digital Twinning of the Human Ventricular Activation Sequence to Clinical 12-lead ECGs and Magnetic Resonance Imaging Using Realistic Purkinje Networks for in Silico Clinical Trials
Julia Camps, Lucas Arantes Berg, Zhinuo Jenny Wang +12
Cardiac in silico clinical trials can virtually assess the safety and efficacy of therapies using human-based modelling and simulation. These technologies can provide mechanistic e…
The Fisher Geometry and Geodesics of the Multivariate Normals, without Differential Geometry
Brodie A. J. Lawson, Kevin Burrage, Kerrie Mengersen +1
Choosing the Fisher information as the metric tensor for a Riemannian manifold provides a powerful yet fundamental way to understand statistical distribution families. Distances al…
Analysis of sloppiness in model simulations: unveiling parameter uncertainty when mathematical models are fitted to data
Gloria M. Monsalve-Bravo, Brodie A. J. Lawson, Christopher Drovandi +7
This work introduces a comprehensive approach to assess the sensitivity of model outputs to changes in parameter values, constrained by the combination of prior beliefs and data. T…
Population Calibration using Likelihood-Free Bayesian Inference
Christopher Drovandi, Brodie Lawson, Adrianne L Jenner +1
In this paper we develop a likelihood-free approach for population calibration, which involves finding distributions of model parameters when fed through the model produces a set o…
Arrhythmogenicity of cardiac fibrosis: fractal measures and Betti numbers
Mahesh Kumar Mulimani, Brodie A. J. Lawson, Rahul Pandit
Infarction- or ischaemia-induced cardiac fibrosis can be arrythmogenic. We use mathematcal models for diffuse fibrosis (), interstitial fibrosis (), pat…
Homogenisation for the monodomain model in the presence of microscopic fibrotic structures
Brodie A. J. Lawson, Rodrigo Weber dos Santos, Ian W. Turner +3
Computational models in cardiac electrophysiology are notorious for long runtimes, restricting the numbers of nodes and mesh elements in the numerical discretisations used for thei…
Inference of ventricular activation properties from non-invasive electrocardiography
Julia Camps, Brodie Lawson, Christopher Drovandi +5
The realisation of precision cardiology requires novel techniques for the non-invasive characterisation of individual patients' cardiac function to inform therapeutic and diagnosti…
Unlocking datasets by calibrating populations of models to data density: a study in atrial electrophysiology
Brodie A. J. Lawson, Christopher C. Drovandi, Nicole Cusimano +3
The understanding of complex physical or biological systems nearly always requires a characterisation of the variability that underpins these processes. In addition, the data used…
Uncertainty quantification of coal seam gas production prediction using Polynomial Chaos
Thomas A. McCourt, Brodie Lawson, Fengde Zhou +3
A surrogate model approximates a computationally expensive solver. Polynomial Chaos is a method to construct surrogate models by summing combinations of carefully chosen polynomial…