906 citations · 1.5k across the 4 of their papers we have counts for
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q-bio.QM2017★ 22 cited
Population-specific design of de-immunized protein biotherapeutics
Benjamin Schubert, Charlotta Schärfe, Pierre Dönnes +3
Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic…
q-bio.GN2017★ 3 cited
Genetic variation in human drug-related genes
Charlotta P. I. Schärfe, Roman Tremmel, Matthias Schwab +2
Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classical pharmacokinetic genes is rather well unders…