3 papers
stat.CO2026
Observed Fisher Information in hidden Markov models - Application to a noisy Gaussian random walk
Alexandra Lefebvre, Grégory Nuel
In this work we provide analytical and closed-form expressions for the exact computation of the score and the observed Fisher information matrix in a Gaussian random walk observed…
q-bio.QM2025
Unsupervised detection and fitness estimation of emerging SARS-CoV-2 variants. Application to wastewater samples (ANRS0160)
Alexandra Lefebvre, Vincent Maréchal, Arnaud Gloaguen +3
Repeated waves of emerging variants during the SARS-CoV-2 pandemics have highlighted the urge of collecting longitudinal genomic data and developing statistical methods based on ti…
stat.AP2017
Computing Individual Risks based on Family History in Genetic Disease in the Presence of Competing Risks
G Nuel, Antoine Lefebvre, O Bouaziz
When considering a genetic disease with variable age at onset (ex: diabetes , familial amyloid neuropathy, cancers, etc.), computing the individual risk of the disease based on fam…