144 citations · 260 across the 6 of their papers we have counts for
3 papers · 1 filter
Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy
Feng Fu, Martin A. Nowak, Sebastian Bonhoeffer
Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity…
The effect of spatial scales on the reproductive fitness of plant pathogens
Alexey Mikaberidze, Christopher C. Mundt, Sebastian Bonhoeffer
Plant diseases often cause serious yield losses in agriculture. A pathogen's reproductive fitness can be quantified by the basic reproductive number, R0. Since pathogen transmissio…
How to develop smarter host mixtures to control plant disease?
Alexey Mikaberidze, Bruce McDonald, Sebastian Bonhoeffer
A looming challenge for agriculture is sustainable intensification of food production to feed the growing human population. Current chemical and genetic technologies used to manage…