381 citations · 1.8k across the 16 of their papers we have counts for
16 papers
Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates
Yi-Hsuan Lin, Tae Hun Kim, Suman Das +6
Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The…
Numerical Techniques for Applications of Analytical Theories to Sequence-Dependent Phase Separations of Intrinsically Disordered Proteins
Yi-Hsuan Lin, Jonas Wessén, Tanmoy Pal +2
Biomolecular condensates, physically underpinned to a significant extent by liquid-liquid phase separation (LLPS), are now widely recognized by numerous experimental studies to be…
Assembly of Model Postsynaptic Densities Involves Interactions Auxiliary to Stoichiometric Binding
Yi-Hsuan Lin, Haowei Wu, Bowen Jia +2
The assembly of functional biomolecular condensates often involves liquid-liquid phase separation (LLPS) of proteins with multiple modular domains, which can be folded or conformat…
A Simple Explicit-Solvent Model of Polyampholyte Phase Behaviors and its Ramifications for Dielectric Effects in Biomolecular Condensates
Jonas Wessén, Tanmoy Pal, Suman Das +2
Biomolecular condensates such as membraneless organelles, underpinned by liquid-liquid phase separation (LLPS), are important for physiological function, with electrostatics -- amo…
Comparative Roles of Charge, and Hydrophobic Interactions in Sequence-Dependent Phase Separation of Intrinsically Disordered Proteins
Suman Das, Yi-Hsuan Lin, Robert M. Vernon +2
Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for biomolecular condensates underlain by liquid-liquid phase separation (LLPS), we conducted mult…
Analytical Theory for Sequence-Specific Binary Fuzzy Complexes of Charged Intrinsically Disordered Proteins
Alan N. Amin, Yi-Hsuan Lin, Suman Das +1
Intrinsically disordered proteins (IDPs) are important for biological functions. In contrast to folded proteins, molecular recognition among certain IDPs is "fuzzy" in that their b…
A unified analytical theory of heteropolymers for sequence-specific phase behaviors of polyelectrolytes and polyampholytes
Yi-Hsuan Lin, Jacob P. Brady, Hue Sun Chan +1
The physical chemistry of liquid-liquid phase separation (LLPS) of polymer solutions bears directly on the assembly of biologically functional droplet-like bodies from proteins and…
Coarse-Grained Residue-Based Models of Disordered Protein Condensates: Utility and Limitations of Simple Charge Pattern Parameters
Suman Das, Alan Amin, Yi-Hsuan Lin +1
Biomolecular condensates undergirded by phase separations of proteins and nucleic acids serve crucial biological functions. To gain physical insights into their genetic basis, we s…
A Lattice Model of Charge-Pattern-Dependent Polyampholyte Phase Separation
Suman Das, Adam Eisen, Yi-Hsuan Lin +1
In view of recent intense experimental and theoretical interests in the biophysics of liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs), heteropolym…
Charge Pattern Matching as a "Fuzzy" Mode of Molecular Recognition for the Functional Phase Separations of Intrinsically Disordered Proteins
Yi-Hsuan Lin, Jacob P. Brady, Julie D. Forman-Kay +1
Biologically functional liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is driven by interactions encoded by their amino acid sequences. Little is curren…
Phase separation and single-chain compactness of charged disordered proteins are strongly correlated
Yi-Hsuan Lin, Hue Sun Chan
Liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is a major undergirding factor in the regulated formation of membraneless organelles in the cell. The pha…
RBPBind: Quantitative prediction of Protein-RNA Interactions
Jeff Gaither, Yi-Hsuan Lin, Ralf Bundschuh
Summary: We introduce RBPBind, a web-based tool for the quantitative prediction of RNA-protein interactions. Given a user-specified RNA and a protein selected from a set of several…
Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins
Yi-Hsuan Lin, Jianhui Song, Julie D. Forman-Kay +1
Intrinsically disordered proteins (IDPs) are typically low in nonpolar/hydrophobic but relatively high in polar, charged, and aromatic amino acid compositions. Some IDPs undergo li…
Sequence-specific polyampholyte phase separation in membraneless organelles
Yi-Hsuan Lin, Julie D. Forman-Kay, Hue Sun Chan
Liquid-liquid phase separation of charge/aromatic-enriched intrinsically disordered proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the p…
RNA structure generates natural cooperativity between single-stranded RNA binding proteins targeting 5' and 3'UTRs
Yi-Hsuan Lin, Ralf Bundschuh
In post-transcriptional regulation, an mRNA molecule is bound by many proteins and/or miRNAs to modulate its function. To enable combinatorial gene regulation, these binding partne…
Interplay between single-stranded binding proteins on RNA secondary structure
Yi-Hsuan Lin, Ralf Bundschuh
RNA protein interactions control the fate of cellular RNAs and play an important role in gene regulation. An interdependency between such interactions allows for the implementation…