184 citations · 1.5k across the 52 of their papers we have counts for
4 papers · 1 filter
Specific protein-protein binding in many-component mixtures of proteins
Richard P. Sear
Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically…
Instabilities in complex mixtures with a large number of components
Richard P. Sear, Jose A. Cuesta
Inside living cells are complex mixtures of thousands of components. It is hopeless to try to characterise all the individual interactions in these mixtures. Thus, we develop a sta…
Solution stability, neutral evolution and variability in a simple model of globular proteins
Richard P. Sear
It is well known amongst molecular biologists that proteins with a common ancestor and that perform the same function in similar organisms, can have rather different amino-acid seq…
Protein crystals and charged surfaces: interactions and heterogeneous nucleation
Richard P. Sear
As proteins typically have charges of around 10, they will interact strongly with charged surfaces. We calculate the electrostatic contribution to the interaction of crystals of pr…