227 citations · 364 across the 12 of their papers we have counts for
3 papers · 1 filter
Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization
Fatima Batool, Ashish Patel, Dipender Gill +1
When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the…
Selecting invalid instruments to improve Mendelian randomization with two-sample summary data
Ashish Patel, Francis J. DiTraglia, Verena Zuber +1
Mendelian randomization (MR) is a widely-used method to estimate the causal relationship between a risk factor and disease. A fundamental part of any MR analysis is to choose appro…
Statistical Methods for cis-Mendelian Randomization with Two-sample Summary-level Data
Apostolos Gkatzionis, Stephen Burgess, Paul J. Newcombe
Mendelian randomization is the use of genetic variants to assess the existence of a causal relationship between a risk factor and an outcome of interest. Here, we focus on two-samp…