1 citations · 1 across the 3 of their papers we have counts for
3 papers
q-bio.QM2005★ 1 cited
Robustness and Evolvability of the B Cell Mutator Mechanism
Patricia Theodosopoulos, Ted Theodosopoulos
We present a model that considers the maturation of the antibody population following primary antigen presentation as a global optimization problem. The trade-off that emerges from…
q-bio.QM2004
Evolution at the Edge of Chaos: A Paradigm for the Maturation of the Humoral Immune Response
Patricia Theodosopoulos, Ted Theodosopoulos
We study the maturation of the antibody population following primary antigen presentation as a global optimization problem. Emphasis is placed on the trade-off between the safety o…
q-bio.QM2004
A computational study of the statistical mechanics of antibody-antigen conformations
Patricia Theodosopoulos, Ted Theodosopoulos
We describe the representation of the chemical affinity between the antigen-combining site of the immunoglobulin molecule and the antigen molecule as the probability of the two mol…