138 citations · 315 across the 15 of their papers we have counts for
11 papers · 1 filter
Should public health policy exempt cases with low viral load from isolation during an epidemic?: a modelling study
Jiahao Diao, Rebecca H. Chisholm, Nicholas Geard +1
During the COVID-19 pandemic, case isolation emerged as a key non-pharmaceutical intervention in pandemic response. Its effectiveness hinges on the timing of isolation, which is of…
COVID-19 in low-tolerance border quarantine systems: impact of the Delta variant of SARS-CoV-2
Cameron Zachreson, Freya M. Shearer, David J. Price +4
In controlling transmission of COVID-19, the effectiveness of border quarantine strategies is a key concern for jurisdictions in which the local prevalence of disease and immunity…
Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure
Somya Mehra, Eva Stadler, David Khoury +2
Malaria is a mosquito-borne disease with a devastating global impact. Plasmodium vivax is a major cause of human malaria beyond sub-Saharan Africa. Relapsing infections, driven by…
An activation-clearance model for Plasmodium vivax malaria
Somya Mehra, James M. McCaw, Mark B. Flegg +2
Malaria is an infectious disease with an immense global health burden. Plasmodium vivax is the most geographically widespread species of malaria. Relapsing infections, caused by th…
Sequential infection experiments for quantifying innate and adaptive immunity during influenza infection
Ada W. C. Yan, Sophie G. Zaloumis, Julie A. Simpson +1
Laboratory models are often used to understand the interaction of related pathogens via host immunity. For example, recent experiments where ferrets were exposed to two influenza s…
Infection-acquired versus vaccine-acquired immunity in an SIRWS model
Tiffany Leung, Barry D Hughes, Federico Frascoli +2
Despite high vaccine coverage, pertussis has re-emerged as a public health concern in many countries. One hypothesis posed for re-emergence is the waning of immunity. In some disea…
A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis +6
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives---the most effective and widely-used antimalarials that…
A biological model of scabies infection dynamics and treatment explains why mass drug administration does not lead to elimination
M. Lydeamore, P. T. Campbell, D. G. Regan +7
Despite a low global prevalence, infections with Sarcoptes scabiei, or scabies, are still common in remote communities such as in northern Australia and the Solomon Islands. Mass d…
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis +8
Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria. With alternative antimalarial drugs not yet available, improving our und…
Periodic solutions in an SIRWS model with immune boosting and cross-immunity
Tiffany Leung, Barry D. Hughes, Federico Frascoli +1
Incidence of whooping cough, an infection caused by Bordetella pertussis and Bordetella parapertussis, has been on the rise since the 1980s in many countries. Immunological interac…
Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host
Ada W. C. Yan, Pengxing Cao, Jane M. Heffernan +5
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a sho…