81 citations · 275 across the 14 of their papers we have counts for
15 papers
The role of viral dynamics and infectivity in models of oncolytic virotherapy for tumours with different motility
David Morselli, Federico Frascoli, Marcello Edoardo Delitala
The use of ad-hoc engineered viruses in the fight against tumours is one of the greatest ideas in cancer therapeutics within the last three decades. Together with other strategies…
A phenotype-structured mathematical model for the influence of hypoxia on oncolytic virotherapy
David Morselli, Giulia Chiari, Federico Frascoli +1
The effectiveness of oncolytic virotherapy is significantly affected by several elements of the tumour microenvironment, which reduce the ability of the virus to infect cancer cell…
A hybrid discrete-continuum modelling approach for the interactions of the immune system with oncolytic viral infections
David Morselli, Marcello E. Delitala, Adrianne L. Jenner +1
Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-cancer immune responses, has garnered significant attention in recent years. In our…
Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses
David Morselli, Marcello Edoardo Delitala, Federico Frascoli
The use of oncolytic viruses as cancer treatment has received considerable attention in recent years, however the spatial dynamics of this viral infection is still poorly understoo…
The role of viral infectivity in oncolytic virotherapy outcomes: A mathematical study
Pantea Pooladvand, Chae-Ok Yun, A-Rum Yoon +2
A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by unin…
Oncolytic virotherapy for tumours following a Gompertz growth law
Adrianne L. Jenner, Peter S. Kim, Federico Frascoli
We present a mathematical model describing oncolytic virotherapy treatment of a tumour that proliferates according to a Gompertz growth function. We present local stability analysi…
Effects of mutations and immunogenicity on outcomes of anti-cancer therapies for secondary lesions
Elena Piretto, Marcello Delitala, Peter S. Kim +1
Cancer development is driven by mutations and selective forces, including the action of the immune system and interspecific competition. When administered to patients, anti-cancer…
Diffusion and escape from polygonal channels: extreme values and geometric effects
Jordan Orchard, Lamberto Rondoni, Carlos Mejia-Monasterio +1
Polygonal billiards are an example of pseudo-chaotic dynamics, a combination of integrable evolution and sudden jumps due to conical singular points that arise from the corners of…
Computation of the equilibrium three-particle entropy for dense atomic fluids by molecular dynamics simulation
Luca Maffioli, Nathan Clisby, Federico Frascoli +1
We have computed the two and three-particle contribution to the entropy of a Weeks-Chandler-Andersen fluid via molecular dynamics simulations. The three-particle correlation functi…
Wave turbulence and intermittency in directional sea states
Elmira Fadaeiazar, Alberto Alberello, Miguel Onorato +4
The evolution of surface gravity waves is driven by nonlinear interactions that trigger an energy cascade similarly to the one observed in hydrodynamic turbulence. This process, kn…
Infection-acquired versus vaccine-acquired immunity in an SIRWS model
Tiffany Leung, Barry D Hughes, Federico Frascoli +2
Despite high vaccine coverage, pertussis has re-emerged as a public health concern in many countries. One hypothesis posed for re-emergence is the waning of immunity. In some disea…
Observation of turbulence in wave-induced oscillatory flows
Alberto Alberello, Federico Frascoli, Miguel Onorato +1
The dynamic and thermal regimes of climate are regulated by an exchange of energy and momentum between the atmosphere and the ocean. The role exerted by surface waves on this inter…
Wind generated rogue waves in an annular wave flume
A. Toffoli, D. Proment, H. Salman +7
We investigate experimentally the statistical properties of a wind-generated wave field and the spontaneous formation of rogue waves in an annular flume. Unlike many experiments on…
Periodic solutions in an SIRWS model with immune boosting and cross-immunity
Tiffany Leung, Barry D. Hughes, Federico Frascoli +1
Incidence of whooping cough, an infection caused by Bordetella pertussis and Bordetella parapertussis, has been on the rise since the 1980s in many countries. Immunological interac…
Metabifurcation analysis of a mean field model of the cortex
Federico Frascoli, Lennaert van Veen, Ingo Bojak +1
Mean field models (MFMs) of cortical tissue incorporate salient features of neural masses to model activity at the population level. One of the common aspects of MFM descriptions i…