3 papers
stat.ME2022
Modeling synergism in early phase cancer trials with drug combination with continuous dose levels: is there an added value?
Mourad Tighiouart, José L. Jiménez, Marcio A. Diniz +1
In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there…
stat.AP2021
Visualizing adverse events in clinical trials using correspondence analysis with R-package visae
Márcio A. Diniz, Gillian Gresham, Sungjin Kim +6
We propose to apply stacked CA using contribution biplots as a tool to explore differences in AE data among treatments in clinical trials. We defined five levels of refinement for…
stat.ME2017
Comparison between continuous and discrete doses using Escalation With Overdose Control
Márcio Augusto Diniz, Mourad Tighiouart, André Rogatko
Although there is an extensive statistical literature showing the disadvantages of discretizing continuous variables, categorization is a common practice in clinical research which…