96 citations · 241 across the 7 of their papers we have counts for
7 papers
Exact solution of stochastic gene expression models with bursting, cell cycle and replication dynamics
Casper H. L. Beentjes, Ruben Perez-Carrasco, Ramon Grima
The bulk of stochastic gene expression models in the literature do not have an explicit description of the age of a cell within a generation and hence they cannot capture events su…
Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks
Karen M. Page, Ruben Perez-Carrasco
Ring oscillators are biochemical circuits consisting of a ring of interactions capable of sustained oscillations. The non-linear interactions between genes hinder the analytical in…
The power of the AC-DC circuit: Operating principles of a simple multi-functional transcriptional network motif
Ruben Perez-Carrasco, Chris P. Barnes, Yolanda Schaerli +3
Genetically encoded regulatory circuits control biological function. A major focus of systems biology is to understand these circuits by establishing the relationship between speci…
Memory functions reveal structural properties of gene regulatory networks
Edgar Herrera-Delgado, Ruben Perez-Carrasco, James Briscoe +1
Gene regulatory networks (GRNs) control cellular function and decision making during tissue development and homeostasis. Mathematical tools based on dynamical systems theory are of…
Minimum Action Path theory reveals the details of stochastic biochemical transitions out of oscillatory cellular states
Roberto de la Cruz, Ruben Perez-Carrasco, Pilar Guerrero +2
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Tran- sitions between such states are studied as noise-driven escape problems in the chem…
Intrinsic noise profoundly alters the dynamics and steady state of morphogen-controlled bistable genetic switches
Ruben Perez-Carrasco, Pilar Guerrero, James Briscoe +1
During tissue development, patterns of gene expression determine the spatial arrangement of cell types. In many cases, gradients of secreted signaling molecules - morphogens - guid…
Modeling the mechano-chemistry of the ϕ29 DNA translocation motor
R. Perez-Carrasco, A. Fiasconaro, F. Falo +1
We present a study of the DNA translocation of the bacteriophage ϕ29 packaging molecular motor. From the experimental available information we present a model system based in an st…