56 citations · 256 across the 37 of their papers we have counts for
16 papers · 1 filter
ARO: Aligned Representation learning for multi-Omics data
Amogh Singh, Yash Shah, Chiara D'Ercoli +4
The high cost of functional molecular assays, and prevalence of missing modalities and unmatched samples in computational biology, create significant barriers to comprehensive mult…
Theoretical Guarantees for Causal Discovery on Large Random Graphs
Mathieu Chevalley, Arash Mehrjou, Patrick Schwab
We investigate theoretical guarantees for the false-negative rate (FNR) -- the fraction of true causal edges whose orientation is not recovered, under single-variable random interv…
In-silico biological discovery with large perturbation models
Djordje Miladinovic, Tobias Höppe, Mathieu Chevalley +6
Data generated in perturbation experiments link perturbations to the changes they elicit and therefore contain information relevant to numerous biological discovery tasks -- from u…
Efficient Differentiable Discovery of Causal Order
Mathieu Chevalley, Arash Mehrjou, Patrick Schwab
In the algorithm Intersort, Chevalley et al. (2024) proposed a score-based method to discover the causal order of variables in a Directed Acyclic Graph (DAG) model, leveraging inte…
Deriving Causal Order from Single-Variable Interventions: Guarantees & Algorithm
Mathieu Chevalley, Patrick Schwab, Arash Mehrjou
Targeted and uniform interventions to a system are crucial for unveiling causal relationships. While several methods have been developed to leverage interventional data for causal…
The CausalBench challenge: A machine learning contest for gene network inference from single-cell perturbation data
Mathieu Chevalley, Jacob Sackett-Sanders, Yusuf Roohani +15
In drug discovery, mapping interactions between genes within cellular systems is a crucial early step. Such maps are not only foundational for understanding the molecular mechanism…
Federated Causal Discovery From Interventions
Amin Abyaneh, Nino Scherrer, Patrick Schwab +3
Causal discovery serves a pivotal role in mitigating model uncertainty through recovering the underlying causal mechanisms among variables. In many practical domains, such as healt…
From Points to Functions: Infinite-dimensional Representations in Diffusion Models
Sarthak Mittal, Guillaume Lajoie, Stefan Bauer +1
Diffusion-based generative models learn to iteratively transfer unstructured noise to a complex target distribution as opposed to Generative Adversarial Networks (GANs) or the deco…
CausalBench: A Large-scale Benchmark for Network Inference from Single-cell Perturbation Data
Mathieu Chevalley, Yusuf Roohani, Arash Mehrjou +2
Causal inference is a vital aspect of multiple scientific disciplines and is routinely applied to high-impact applications such as medicine. However, evaluating the performance of…
Federated Learning in Multi-Center Critical Care Research: A Systematic Case Study using the eICU Database
Arash Mehrjou, Ashkan Soleymani, Annika Buchholz +3
Federated learning (FL) has been proposed as a method to train a model on different units without exchanging data. This offers great opportunities in the healthcare sector, where l…
GalilAI: Out-of-Task Distribution Detection using Causal Active Experimentation for Safe Transfer RL
Sumedh A Sontakke, Stephen Iota, Zizhao Hu +3
Out-of-distribution (OOD) detection is a well-studied topic in supervised learning. Extending the successes in supervised learning methods to the reinforcement learning (RL) settin…
GeneDisco: A Benchmark for Experimental Design in Drug Discovery
Arash Mehrjou, Ashkan Soleymani, Andrew Jesson +4
In vitro cellular experimentation with genetic interventions, using for example CRISPR technologies, is an essential step in early-stage drug discovery and target validation that s…
Diffusion-Based Representation Learning
Sarthak Mittal, Korbinian Abstreiter, Stefan Bauer +2
Diffusion-based methods represented as stochastic differential equations on a continuous-time domain have recently proven successful as a non-adversarial generative model. Training…
Causal Curiosity: RL Agents Discovering Self-supervised Experiments for Causal Representation Learning
Sumedh A. Sontakke, Arash Mehrjou, Laurent Itti +1
Animals exhibit an innate ability to learn regularities of the world through interaction. By performing experiments in their environment, they are able to discern the causal factor…
Kernel-Guided Training of Implicit Generative Models with Stability Guarantees
Arash Mehrjou, Wittawat Jitkrittum, Krikamol Muandet +1
Modern implicit generative models such as generative adversarial networks (GANs) are generally known to suffer from issues such as instability, uninterpretability, and difficulty i…
Fidelity-Weighted Learning
Mostafa Dehghani, Arash Mehrjou, Stephan Gouws +2
Training deep neural networks requires many training samples, but in practice training labels are expensive to obtain and may be of varying quality, as some may be from trusted exp…