148 citations · 350 across the 5 of their papers we have counts for
5 papers
Cluster size determines internal structure of transcription factories in human cells
Massimiliano Semeraro, Giuseppe Negro, Giada Forte +4
Transcription is a fundamental cellular process, and the first step of gene expression. In human cells, it depends on the binding to chromatin of various proteins, including RNA po…
Simulating topological domains in human chromosomes with a fitting-free model
C. A. Brackley, D. Michieletto, F. Mouvet +4
We discuss a polymer model for the 3D organization of human chromosomes. A chromosome is represented by a string of beads, with each bead being "colored" according to 1D bioinforma…
Shaping Epigenetic Memory via Genomic Bookmarking
Davide Michieletto, Michael Chiang, Davide Coli +4
Reconciling the stability of epigenetic patterns with the rapid turnover of histone modifications and their adaptability to external stimuli is an outstanding challenge. Here, we p…
Non-equilibrium chromosome looping via molecular slip-links
C. A. Brackley, J. Johnson, D. Michieletto +4
We propose a model for the formation of chromatin loops based on the diffusive sliding of a DNA-bound factor which can dimerise to form a molecular slip-link. Our slip-links mimic…
Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains
C. A. Brackley, B. Liebchen, D. Michieletto +3
Fluorescence microscopy reveals that the contents of many (membrane-free) nuclear "bodies" exchange rapidly with the soluble pool whilst the underlying structure persists; such obs…