96 citations · 257 across the 11 of their papers we have counts for
11 papers
Flow of deformable droplets: self-pinned glasses and string-like flow
Achille Quarante, Michael Chiang, Davide Marenduzzo +1
We investigate, through numerical simulations, the rheology of a dry suspension of deformable droplets under pressure-driven flow. The system exhibits two force-driven dynamical tr…
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription
Michael Chiang, Cleis Battaglia, Giada Forte +3
Transcriptional noise, or heterogeneity, is important in cellular development and in disease. The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we…
Multiphase Field Model of Cells on a Substrate: From 3D to 2D
Michael Chiang, Austin Hopkins, Benjamin Loewe +2
Multiphase field models have emerged as an important computational tool for understanding biological tissue while resolving single-cell properties. While they have successfully rep…
Topological spectra and entropy of chromatin loop networks
Andrea Bonato, Dom Corbett, Sergey Kitaev +3
The 3D folding of a mammalian gene can be studied by a polymer model, where the chromatin fibre is represented by a semiflexible polymer which interacts with multivalent proteins,…
Combinatorics and topological weights of chromatin loop networks
Andrea Bonato, Dom Corbett, Sergey Kitaev +3
Polymer physics models suggest that chromatin spontaneously folds into loop networks with transcription units (TUs), such as enhancers and promoters, as anchors. Here we use combin…
Intercellular Friction and Motility Drive Orientational Order in Cell Monolayers
Michael Chiang, Austin Hopkins, Benjamin Loewe +2
Spatiotemporal patterns in multicellular systems are important to understanding tissue dynamics, for instance, during embryonic development and disease. Here, we use a multiphase f…