Global optimization of proteins using a dynamical lattice model: Ground states and energy landscapes

Abstract

A simple approach is proposed to investigate the protein structure. Using a low complexity model, a simple pairwise interaction and the concept of global optimization, we are able to calculate ground states of proteins, which are in agreement with experimental data. All possible model structures of small proteins are available below a certain energy threshold. The exact lowenergy landscapes for the trp cage protein (1L2Y) is presented showing the connectivity of all states and energy barriers.

8 pages, 5 figures, changed title and content, Chemical Physics Letters (in press)

References in corpus (3)

• Folding thermodynamics of peptides
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