Optimal Path to Epigenetic Switching

Abstract

We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.

5 pages. 2 figures, uses revtex 4. PR-E reviewed for publication

References in corpus (1)

• Mechanisms of noise-resistance in genetic oscillators

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