Base sequence dependent sliding of proteins on DNA

Abstract

The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered. Referring to the case of the T7 RNA-polymerase, we show that the protein should follow a noise-influenced sequence-dependent motion which deviate from the standard random walk usually assumed. The general validity and the implications of the results are discussed.

12 pages, 3 figures

References in corpus (1)

• Physical Constraints and Functional Characteristics of Transcription Factor-DNA Interaction

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