An asymptotic maximum principle for essentially linear evolution models

Abstract

Recent work on mutation-selection models has revealed that, under specific assumptions on the fitness function and the mutation rates, asymptotic estimates for the leading eigenvalue of the mutation-reproduction matrix may be obtained through a low-dimensional maximum principle in the limit N to infinity (where N is the number of types). In order to extend this variational principle to a larger class of models, we consider here a family of reversible N by N matrices and identify conditions under which the high-dimensional Rayleigh-Ritz variational problem may be reduced to a low-dimensional one that yields the leading eigenvalue up to an error term of order 1/N. For a large class of mutation-selection models, this implies estimates for the mean fitness, as well as a concentration result for the ancestral distribution of types.

31 pages, 2 figures. Thorough revision, additional material included. J. Math. Biol., in press

References in corpus (2)

• A maximum principle for the mutation-selection equilibrium of nucleotide sequences
• Discrete Approximation of Non-Compact Operators Describing Continuum-of-Alleles Models