Analytic models for mechanotransduction: gating a mechanosensitive channel

Abstract

Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich story which can provide both a quantitative comparison to measurements of opening tension for MscL when reconstituted in bilayers of different thickness and qualitative insights into the function of the MscL channel and other transmembrane proteins.

References in corpus (1)

• Ion channel gating: a first passage time analysis of the Kramers type

Cited by in corpus (16)

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• Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins
• A Quantitative Overview of Biophysical Forces Governing Neural Function
• Gating-by-tilt of mechanosensitive membrane channels
• Directional interactions and cooperativity between mechanosensitive membrane proteins
• Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction
• Bilayer-thickness-mediated interactions between integral membrane proteins
• Architecture and Function of Mechanosensitive Membrane Protein Lattices
• Composition variation and underdamped mechanics near membrane proteins and coats
• Mechanosensitive Channel Activation by Diffusio-Osmotic Force
• Role of the membrane for mechanosensing by tethered channels
• Signatures of protein structure in the cooperative gating of mechanosensitive ion channels
• Signatures of Mechanosensitive Gating
• Controlling the shape of membrane protein polyhedra
• Dependence of protein-induced lipid bilayer deformations on protein shape
• Thermodynamic competition between membrane protein oligomeric states