On the codon assignment of chain termination signals and the minimization of the effects of frameshift mutations

Abstract

It has been suggested that the minimization of the probability for lethal mutations is a major constraint shaping the genetic code, with the finding that the genetic code is highly protective against transition mutations. Here, we show that recent data on polymerase-induced frameshifts provide a rationale for the codon assignment of chain termination signals (CTS).

4 pages, LaTeX, two tables available from authors