Influence of fluctuations in actin structure on myosin V step size

Abstract

We study the influence of disorder in the helical actin structure on the myosin V step size, predicted from the elastic lever arm model. We show that fluctuations of +-5 degrees per actin subunit, as proposed by Egelman et al., significantly alter the distribution of step sizes and improve the agreement with experimental data.

5 pages, 4 figures, to appear in J. Chem. Inf. Model

References in corpus (1)

• Elastic lever arm model for myosin V

Cited by in corpus (2)

• Twirling motion of actin filaments in gliding assays with non-processive myosin motors
• Myosin V passing over Arp2/3 junctions: branching ratio calculated from the elastic lever arm model