Molecular recognition in a lattice model: An enumeration study

Abstract

We investigate the mechanisms underlying selective molecular recognition of single heteropolymers at chemically structured planar surfaces. To this end, we study systems with two-letter (HP) lattice heteropolymers by exact enumeration techniques. Selectivity for a particular surface is defined by an adsorption energy criterium. We analyze the distributions of selective sequences and the role of mutations. A particularly important factor for molecular recognition is the small-scale structure on the polymers.

revised version with additional plots

References in corpus (3)

• Why Do Proteins Look Like Proteins?
• Nature of Driving Force for Protein Folding -- A Result From Analyzing the Statistical Potential
• Influence of sequence correlations on the adsorption of random copolymers onto homogeneous planar surfaces

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• Two-State Folding, Folding through Intermediates, and Metastability in a Minimalistic Hydrophobic-Polar Model for Proteins
• Adsorption and Pattern Recognition of Polymers at Complex Surfaces with Attractive Stripe-like Motifs
• A Coarse-Grained Lattice Model for Molecular Recognition
• Polymer Adsorption on Curved Surfaces
• Thermodynamics of the Adsorption of Flexible Polymers on Nanowires
• Coarse-grained lattice model for investigating the role of cooperativity in molecular recognition
• Influence of correlations on molecular recognition
• Dry and wet interfaces: Influence of solvent particles on molecular recognition