Acoustic "distributed source" mixing of smallest fluid volumes

Abstract

Acoustically driven mixing of small fluid volumes is reported. Using surface acoustic waves on a mixer chip, conversion of those into bulk waves, and employing wave guiding effects enables us to distribute a set of "virtual sources" for acoustic streaming over large areas. we demonstrate the applicability of our mixing technique to micro array applications, for mixing of individual wells in a micro titer plate, and other state-of-the-art hybridization assays.