A hierarchical scheme for cooperativity and folding in proteins

Abstract

We propose a protein model based on a hierarchy of constraints that force the protein to follow certain pathways when changing conformation. The model exhibits a first order phase transition, cooperativity and is exactly solvable. It also shows an unexpected symmetry between folding and unfolding pathways as suggested by a recent experiment.

4 pages RevTeX, 4 Postscript figures. Contents substantially revised compared to previous version

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