Computational and Analytical Modeling of Cationic Lipid-DNA Complexes

Abstract

We present a theoretical study of the physical properties of cationic lipid-DNA (CL-DNA) complexes - a promising synthetically based nonviral carrier of DNA for gene therapy. The study is based on a coarse-grained molecular model, which is used in Monte Carlo (MC) simulations of mesoscopically large systems over time scales long enough to address experimental reality. In the present work we focus on the statistical-mechanical behavior of lamellar complexes, which in MC simulations self-assemble spontaneously from a disordered random initial state.

References in corpus (7)

• "Water-free" computer model for fluid bilayer membranes
• Increased Concentration of Polyvalent Phospholipids in the Adsorption Domain of a Charged Protein
• Statistical mechanics of bilayer membrane with a fixed projected area
• Meso-scale computer modeling of lipid-DNA complexes for gene therapy
• Binding of Oppositely Charged Membranes and Membrane Reorganization
• Electrostatically induced undulations of lamellar DNA-lipid complexes
• Effective Interactions Between Rigid Polyelectrolytes and Like-charged Planar Surfaces

Cited by in corpus (3)

• Transitions between distinct compaction regimes in complexes of multivalent cationic lipids and DNA
• Mode excitation Monte Carlo simulations of mesoscopically large membranes
• Small membranes under negative surface tension