A Cooperative Stochastic Model of Gene Expression

Abstract

Recent experiments at the level of a single cell have shown that gene expression occurs in abrupt stochastic bursts. Further, in an ensemble of cells, the levels of proteins produced have a bimodal distribution. In a large fraction of cells, the gene expression is either off or has a high value. We propose a stochastic model of gene expression the essential features of which are stochasticity and cooperative binding of RNA polymerase. The model can reproduce the bimodal behaviour seen in experiments.

4 pages (Revtex), 3 eps figures (included), to be published in IJMPC

Cited by in corpus (3)

• Graded and Binary Responses in Stochastic Gene Expression
• Nonergodisity of a time series obeying Lévy statistics
• Quantifying the noise in bursty gene expression under regulation by small RNAs