Towards Practical Algorithm Selection for Unsupervised Domain Adaptation in Medical Imaging
arXiv:2607.28125
The paper introduces a label‑free criterion that automatically selects the best unsupervised domain adaptation algorithm and its hyperparameters for medical imaging by comparing candidate models to an agreement reference built from multiple selection signals.
Abstract
Numerous unsupervised domain adaptation (UDA) algorithms exist, but for clinical practice, selecting the best-suited one along with proper hyperparameters often remains unclear, as the unlabeled deployment (target) domain prevents direct evaluation. We propose a label-free criterion that jointly selects the algorithm and hyperparameters for UDA. Given a pool of candidate models from multiple algorithms trained with different hyperparameters, our approach scores each candidate against an agreement reference, and selects the one with the highest score. The agreement reference is constructed in two levels without using target labels. First, we leverage multiple label-free selection signals, using each to nominate a model within every algorithm. Second, the nominated models are aggregated across algorithms to form a reference prediction for each unlabeled target sample. The candidate whose predictions agree most with this reference is then selected for deployment. Experimental results on four brain MRI and four chest X-ray datasets across seven clinically relevant transfer scenarios show that our method achieves better selection performance than other methods and remains effective across different algorithm pools. Our approach takes a step towards practical, label-free algorithm selection for clinical deployment of UDA.
Accepted to AMAI @ MICCAI 2026