MoRE: A Mixture-of-Experts-Based Task-Adaptive End-to-End Network for Multimodal MRI Reconstruction

Abstract

Although accelerated MRI reconstruction has advanced rapidly through end-to-end learning, deploying a single unified network that generalizes across diverse anatomies and contrasts under constrained computational resources remains challenging. In this paper, we introduce MoRE, a sparsely activated mixture-of-experts (MoE) module integrated into an end-to-end variational network. MoRE couples a shared encoder with sample-wise, unsupervised routing to activate a minimal subset of expert decoders while strictly preserving physics-based data consistency. Evaluated on the fastMRI multi-coil brain and knee datasets under 8x undersampling, MoRE achieves highly stable SSIM and PSNR performance across multi-contrast datasets. Furthermore, t-SNE visualization of the routing embeddings reveals interpretable, modality-aware expert specialization. The sparse conditional computation mechanism ensures that the architectural overhead remains modest. These results demonstrate that MoE-style capacity scaling can significantly enhance general-purpose MRI reconstruction without requiring proportional increases in computational power.

Accepted at the 2026 48th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2026), Toronto, Canada, July 26-30, 2026