Task-Aligned Self-Supervised Learning for Medical Image Analysis: A Task-Oriented Review with Practical Design Guidelines

Abstract

Self-supervised learning (SSL) is increasingly used in medical image analysis to reduce dependence on costly expert annotations by learning transferable representations from unlabeled data. However, SSL performance depends not only on model architecture but also on whether the self-supervised objective preserves the information required by the downstream clinical task. This review presents a task-oriented synthesis of SSL methods for medical imaging, focusing on how the design of the self-supervised objective interacts with imaging modality, label availability, and downstream performance. We analyze $78$ studies published from 2017 to 2025 and organize them into four paradigms: contrastive, non-contrastive and predictive, generative and reconstruction-based, and hybrid learning. Rather than cataloging methods chronologically, we examine how these paradigms support classification, segmentation, detection, reconstruction, and regression. The evidence suggests that effectiveness is governed by the match among objective, modality, and downstream task rather than by any single strategy. Contrastive objectives favor global discriminative representations suited to classification but may underrepresent localized pathology, whereas spatial-prediction, masked-modeling, and reconstruction objectives better preserve anatomical structure for segmentation and dense prediction. Critically, misaligned objectives can cause negative transfer through shortcut learning on acquisition signatures or augmentation that erases diagnostic signal rather than merely weaker gains. SSL is most beneficial in low-label regimes, but its effectiveness depends on modality-aware augmentation, pathology-preserving corruption, and clinically meaningful evaluation. We conclude with practical design guidelines and open challenges for clinically aligned SSL.

This manuscript is 25 pages