Dynamical analysis in a nonlocal delayed reaction-diffusion tumor model with therapy

Abstract

In this work, we investigate the dynamical properties of a reaction-diffusion system arising from tumor-therapy modelling that features both nonlinear interactions and nonlocal delay. By applying the Lyapunov-Schmidt reduction, we establish the existence of a nontrivial steady-state solution bifurcating from the trivial solution. In particular, we derive an approximate expression for a spatially nonhomogeneous steady-state solution. Then, we provide a detailed spectral characterization of the linearized operator and explicit stability criteria and identify the delay-dependent Hopf bifurcation regimes. To illustrate the theoretical results, we include a concrete example that verifies the claims in our theorems and numerically demonstrates how changes in treatment parameters alter stability and bifurcation behaviour.