Cine MRI-Validated Biventricular Electromechanical Digital Twin Framework for Predicting Regional Endocardial Motion

Abstract

Personalized cardiovascular medicine increasingly relies on digital twin frameworks to translate clinical imaging into patient-specific functional insights. This work presents a biventricular electromechanical human heart model for predicting regional endocardial motion. The model integrates realistic 3D cardiac geometry, rule-based myocardial fiber orientation, reaction-diffusion electrophysiology, voltage-dependent active stress, closed-loop systemic and pulmonary hemodynamics, and two-way fluid-structure interaction with explicit 3D blood domains. Mechanical boundary conditions are also introduced to represent the influence of surrounding tissues on cardiac motion. The model was validated against Cine magnetic resonance imaging (MRI)-derived right ventricular motion, demonstrating consistent regional motion patterns between simulation and imaging results. The validated framework enables quantitative assessment of regional endocardial displacement and velocity, supporting the identification of mechanically favorable implantation regions for motion-driven intracardiac devices. The results further highlight that implantation-site selection should consider not only local motion amplitude, but also anatomical safety and electrophysiological suitability. Overall, the proposed Cine MRI-validated electromechanical digital twin framework provides a predictive platform for regional endocardial motion analysis and establishes a foundation for future patient-specific planning of self-powered intracardiac implants prior to clinical implementation.