A Mathematical and Optimal Control Model for Rabies Transmission Dynamics Among Humans and Dogs with Environmental Effects

Abstract

This study presents a deterministic model to investigate rabies transmission dynamics, incorporating environmental effects and control strategies using optimal control theory. Qualitative and quantitative analyses reveal that the disease-free equilibrium is stable when the effective reproduction number ${\mathcal{R}}_e<1$, and unstable when ${\mathcal{R}}_e>1$. Mesh and contour plots illustrate an inverse relationship between ${\mathcal{R}}_e$ and control strategies, including dog vaccination, health promotion, and post-exposure treatment. Increased intervention reduces transmission, while higher contact rates among dogs raise ${\mathcal{R}}_e$. Numerical simulations with optimal control confirm the effectiveness of integrated strategies. Vaccination and treatment are identified as key interventions for achieving rabies elimination within five years.

This is a preprint version of the paper published open access in 'Journal of Applied Mathematics' at [https://onlinelibrary.wiley.com/journal/4185]